PhD candidate 'Clinical and technical validation of Generative AI-based Digital Twins for cardiovascular imaging'

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PhD candidate 'Clinical and technical validation of Generative AI-based Digital Twins for cardiovascular imaging'

Apply

Your role

Cardiovascular disease remains a leading cause of mortality, while the predictive value of routinely acquired imaging and clinical data is still underutilized. Within the Horizon Europe TWIN-X project, generative AI is used to build multimodal digital patient twins that integrate imaging, clinical data, and longitudinal health trajectories.

In this PhD, you will focus on a critical and currently underdeveloped aspect: rigorous clinical validation of these systems. Rather than developing models, your work will determine whether digital twins provide reliable, generalizable, and clinically meaningful predictions across institutions and patient populations.

You will design and conduct validation studies, including multi-site external evaluations and clinical reader studies. Using large-scale datasets (coronary CT, aortic CT, cardiac MRI), you will assess model performance, calibration, robustness, and behaviour under real-world conditions. In parallel, you will contribute to the development of structured reporting approaches that make AI outputs interpretable and reproducible in clinical workflows. You and your work are expected to be highly visible, so you'll be able to build presentation and reseach communication skills.

This position is embedded in a large international consortium of 19 partners across Europe, including TU Munich, University of Crete, 3R Swiss Imaging Network, EuSoMII, and others. You will collaborate with leading groups in medical AI and contribute to widely used benchmarking infrastructures such as Grand Challenge.

Part of TWIN-X | Horizon Europe | Call: HORIZON-HLTH-2025-01-TOOL-03 | 19 partner institutions across 9 European countries

Preferred start date: 1 September 2026

Your workplace

You will be based in the Department of Medical Imaging at Radboud University Medical Center (Radboudumc), embedded in the Diagnostic Image Analysis Group (DIAG). DIAG is one of Europe's leading research groups in medical image analysis, with researchers across Radiology and Nuclear Medicine, Pathology, and Cardiology. The working atmosphere is collaborative, international, and impact & research driven.

This project represents a novel dimension for the group: a bridge toward rigorous real-world clinical evaluation of AI. Radboudumc operates the Grand Challenge platform— a globally used infrastructure for benchmarking medical imaging AI — which you will work with directly. The group has a strong track record of publishing in high-impact journals.

You will be (hybridly but personally) supervised by Dr M. Huisman (PI), attending cardiovascular and musculoskeletal radiologist and Vice President Elect of EuSoMII, with expertise in clinical AI validation, post-market surveillance, and standardization of AI as a regulated clinical technology. Your promotor is Prof. Henkjan Huisman (DIAG, Radiology). You will work relatively independently, embedded within a group with strong technical expertise in imaging AI and have regular interaction with international partners across the TWIN-X consortium. Hybrid working is an option, depending on individual factors and project requirements.

At the department of Medical Imaging, you work on diagnostics, interventions, education, and scientific research. Our focus spans three key areas: Radiology, Nuclear Medicine, and Anatomy. Together with your colleagues, you contribute to the early detection of diseases and the improvement of treatments, helping us make healthcare more precise and patient friendly.

Your profile

The ideal candidate is an intellectually independent, highly intrinsically motivated researcher with a strong interest in bridging AI development and clinical evidence generation. Success in this position requires the ability to translate technical AI methods into clinically meaningful evaluation frameworks, while working effectively in a multidisciplinary and international environment. A flexible, resourceful, and proactive mindset is essential, with strong ownership of work, the ability to structure and drive projects independently, and to thrive in a setting with high autonomy and trust.

Education

You have a MSc degree in a relevant field such as Technical Medicine, Biomedical Engineering, Medical Image Analysis, Medical Informatics, Statistics, Computer Science, or a related discipline.

Experience & competencies

  • High AI literacy: you follow current developments in large language models, foundation models, and agentic AI; you can place new techniques in context and critically evaluate their relevance.
  • Experience running or evaluating AI models, working with LLM APIs, or building (agentic) pipelines.
  • Experience with medical imaging data formats, reader studies, NLP or text extraction pipelines, or evaluation platforms such as Grand Challenge is an advantage.
  • Programming experience in any modern language or tool.
  • A basic understanding of clinical research methodology; deep clinical expertise is not required and will be provided through supervision.
  • Scientific writing and presenting skills.
  • Working proficiency in English (C1-C2).

Good to know

  • This is a 4-year PhD position within the TWIN-X Horizon Europe consortium (HORIZON-HLTH-2025-01-TOOL-03)
  • This position requires a Certificate of Conduct (VOG).

We are recruiting for this position ourselves. Unsolicited marketing is not appreciated, but do feel free to share the vacancy in your network!

Want to know more?

We’re happy to provide more information!

Merel Huisman

Attractive employment conditions

Advancing healthcare through impactful research

Contribute to groundbreaking research that drives innovations in health and the healthcare of the future.

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